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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2022.11(7): 237-246
DOI: https://doi.org/10.20546/ijcmas.2022.1107.028


Synthesis, Characterization and Application of 1, 10 Phenanthroline and 2, 6 Pyridine Dicarboxamide Ligands Supported Five Coordinated Cu (II) System for DNA Binding and Antibacterial Activity
1Department of Chemistry, Arignar Anna Government Arts College, Cheyyar – 604407,
Tamil Nadu, India
2Department of Chemistry, Thiruvalluvar University, Serkkadu, Vellore - 632 115,
Tamil Nadu, India
*Corresponding author
Abstract:

The copper (II) complex [Cu(1,10-phen)(2,6-pyridinedicarboxamide)](NO3)2 has been synthesized and characterized by Fourier transform infrared spectroscopy (FT-IR), Ultraviolet-visible spectroscopy (UV), Electron paramagnetic resonance spectroscopy (EPR) and Photoluminescence (PL) analysis. The copper complex was connected to two sides, 1,10-phenanthroline and 2,6 py-dicarboxamide ligands, providing a five-coordinate Cu (II) complex. The commercial heterocyclic base coordinated copper metal complex was found to have antimicrobial activity against Gram-positive and gram-negative bacteria. It is noted that the commercial ligand with a copper metal complex was found to be more biologically active, and the DNA-binding properties of the copper complex were investigated by UV, PL, and cyclic voltammetry measurements. The obtained results indicate that the Cu (II) complex binding in DNA through an intercalation mode and the binding constant (Kb) value of the complex as 1.9 × 104 M−1, respectively.


Keywords: Copper (II) complex, DNA binding,Five coordination system,Antibacterial activity
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How to cite this article:

Karthik, D and Mahadevimangalam Narayanasamy Arumugham. 2022. Synthesis, Characterization and Application of 1, 10 Phenanthroline and 2, 6 Pyridine Dicarboxamide Ligands Supported Five Coordinated Cu (II) System for DNA Binding and Antibacterial Activity.Int.J.Curr.Microbiol.App.Sci. 11(7): 237-246. doi: https://doi.org/10.20546/ijcmas.2022.1107.028