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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2021.10(9): 567-577
DOI: https://doi.org/10.20546/ijcmas.2021.1009.065


Chronic Toxicity Study of Aqueous Roots Extract of Rauvolfia vomitoria AFZEL on Haematological Parameters in Wistar Rats
Roland Patrick N’Cho1*, Mama Koné1, Moussa Gbogbo2, N’Guessan Jean Baptiste Oussou1 and Angoué Paul Yapo1
1Laboratory of Physiology, Pharmacology and Pharmacopoeia, UFR-SN, University of Nangui Abrogoua, P.O.Box 801, Abidjan 02, Côte d’Ivoire 2Department of Biochemistry and Microbiology, Lorougnon Guédé University Daloa, P.O.Box 150, Daloa, Côte d’Ivoire
*Corresponding author
Abstract:

Rauvolfia vomitoria Afzel. (Apocynaceae) is a plant used in traditional medicine in Côte d'Ivoire for the treatment of several conditions. This work aims to evaluate the effects of repeated oral administration of the aqueous roots extract Rauvolfia vomitoria AFZEL (AERv) on haematological parameters in Wistar rats. Thus, 100 healthy rats were divided into four groups (T, A, B, C) of 20 rats each. The sub groups Ts and Cs from the groups T and C included 10 rats (5 males and 5 females) were formed for a reversibility study. After 6 months (180 days) of the experiment, the sub groups rats Ts and Cs were no more treated with the extract till the 210th day (7 months), day of their sacrifice to verify the reversibility and/or delayed effects of AERv. The erythrocyte, platelet and leukocyte parameters were determined. Results showed that AERv caused a significant decrease in erythrocyte and thrombocyte parameters with the high dose (1000 mg/kg bw) while an increase in leukocyte parameters was noted in a dose-dependent manner. The aqueous extract of the barkless roots is not harmful at the therapeutic dose of 700 mg/kg bw on the haematological parameters. After stoping administration the effects were reversible.


Keywords: Rauvolfia vomitoria, chronic toxicity, haematological parameters, reversibility, rats
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How to cite this article:

Roland Patrick N’Cho, Mama Koné, Moussa Gbogbo, N’Guessan Jean Baptiste Oussou and Angoué Paul Yapo. 2021. Chronic Toxicity Study of Aqueous Roots Extract of Rauvolfia vomitoria AFZEL on Haematological Parameters in Wistar Rats.Int.J.Curr.Microbiol.App.Sci. 10(9): 567-577. doi: https://doi.org/10.20546/ijcmas.2021.1009.065