National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Propolis and pollen are apicultural products exhibits valuable pharmacological and biological properties attributed to the presence of polyphenols. So this study designed to investigate the chemical composition, antioxidant and anticancer activity of propolis and pollen extracts. Propolis and pollen extracts were obtained by different concentrations of ethanol. Phenolic compounds of the extracts were detected by high performance liquid chromatography (HPLC) analysis. 25 phenolic compounds and 12 flavonoids from propolis and pollen extracts were identified. The major phenolic compounds were ethyl vanillin and hisperidin. 70% ethanolic extracts of propolis (EEP70) and combined mixtures of ethanolic propolis and pollen extracts (EPP70) has found to exhibit high antioxidant activity which has been measured by 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) assay method. All tested extracts show cytotoxic activity against the two tested cancer cell lines: breast cancer (MCF-7) and liver cancer (Hep-G2) cell lines. Generally, 70% ethanolic extract of propolis (EEP70), water extract of propolis (WEP) and combined mixtures of water extracted propolis and pollen (WPP) show the highest cytotoxic activity. This study may be useful in developing functional foods with high dietary antioxidant content or chemopreventive anticancer drugs with a potential to influence tumor cell progression.
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