National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Phylogenetic analysis of pathogenic microorganisms contributes to better understanding the distribution of genotypes that may be specific of certain regions and maybe associated with an increased virulence or antifungal resistance. This study performed phylogenetic analysis of 105 Sequence Types (ST) described for the VNB genotype of Cryptococcus neoformans available on the MLST database in order to better understand this population structure. We found three main clusters, being Cluster 1 the largest with 83 STs and Cluster 2 the smallest with three STs. In general, the isolates presented high genetic variability with haplotype diversity (HD) of 0.998 and nucleotide diversity (π)of 0.00372.Results also demonstrated recombination events, although PHY test showed no significance (p=5.5511). These findings are important since they illustrate that a genotype previously restricted to Africa and now distributed worldwide presents high genetic variability, with potential impact in the development of increased virulence, antifungal resistance, among other factors.
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