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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2021.10(8): 34-41
DOI: https://doi.org/10.20546/ijcmas.2021.1008.005


Detrimental Effects of Acrylamide Induced Cardiotoxicity and its Amelioration in Adult Male Wistar Rats
Pratishtha Sharma1*, Sharad K. Yadav2, Amit Kumar3, Vinod K. Singh4, Renu Singh5, Vikas Pathak6 and Dilip Kumar Swain7
1Department of Biotechnology,
2Department of Microbiology and Immunology
3Department of Immunology and Defense Mechanism, College of Biotechnology,SVPUAT, Meerut-250110, Uttar Pradesh, India
4Department of Veterinary Pathology,
5Department of Livestock and product management,
6Department of Veterinary Physiology,
7Department of Veterinary Science and Animal Husbandry, U.P. Pandit Deendayal Upadhayaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, Mathura - 281001, Uttar Pradesh, India
*Corresponding author
Abstract:

Present study was designed to evaluate and investigate the cadiotoxicity induced through oral feeding of acrylamide (ACR) and its amelioration strategies using different antioxidants in Wistar rat model. A total number of 32 adult male Wistar rats were divided into eight groups (G1-G8) G1, (Basal Diet only), G2 (α-tocopherol+basal diet), G3 (GSH), G4 (Corn oil), G5 (ACR),G6 (ACR+ α-tocopherol G7 (ACR + GSH) and G8 (ACR + α-tocopherol+ GSH). ACR, α-tocopherol and GSH were orally administered to rats @ 30 mg/KgBW, 5 IU/ KgBW and 2mg/ KgBW, respectively for 45 days. The study revealed significant reduction in body and heart weights in ACR fed rats (G5) compared to control rats (G1-G4) whereas, the weight were significantly restored in (G6-8). Heart tissues were collected after 45th day for the assessment of morphological, biochemical, histopathological and oxidative stress parameters. ACR intoxication resulted in oxidative stress as evident from higher levels of MDA and lower activities of antioxidative enzymes SOD, GSH, GST and CAT in rats (G5) compared to (G1-4). These parameters showed significant (P<0.05) restoration in (G6). Serum biochemical parameters were restored in G6 and G7 compared to G5.Histopathologically, the heart tissues revealed severe degeneration, necrosis and separation of cardiac muscle fibers with extravassation of RBCs in (G5) while it was restored and marked improvement was visible in ameliorating groups (G6-G8) in comparison to (G5). With the end of the study in conclusion it was evident that α-tocopherol and GSH played substantial role in maintaining the balance between oxidant and antioxidant mechanisms and in specific, α-tocopherol conferred better protection from ACR induced cardiotoxicity.


Keywords: Acrylamide, antioxidant, cardiotoxicity, heart, oxidative stress
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How to cite this article:

Pratishtha Sharma, Sharad K. Yadav, Amit Kumar, Vinod K. Singh, Renu Singh, Vikas Pathak and Dilip Kumar Swain. 2021. Detrimental Effects of Acrylamide Induced Cardiotoxicity and its Amelioration in Adult Male Wistar Rats.Int.J.Curr.Microbiol.App.Sci. 10(8): 34-41. doi: https://doi.org/10.20546/ijcmas.2021.1008.005