National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Tapinanthus dodoneifolius (Loranthaceae) is an epiphytic parasitic plant used in the treatment of cholera, asthma, hypertension, and diabetes. The general objective of this study was to evaluate the antidiabetic properties of the aqueous extract of the leaves of T. dodoneifolius (Loranthaceae) in the Wistar rat. Type 1 diabetes was induced by intraperitoneal injection of streptozotocin into the single dose of 60 mg/kg. Seventy-two hours later, rats with blood glucose ≥ 200 mg/dL were selected and treated for 28 days with distilled water, glibenclamide (3 mg/kg) and aqueous extract of T.dodoneifolius at doses of 125, 250 and 500 mg/kg. Body weight, blood sugar, and food and water intake were measured during treatment. At the end of treatment, serum insulin level, lipid profile and oxidative stress parameters were assessed. Results showed that administration of the extract of T. dodoneifolius leaves at doses of 250 and / or 500 mg/kg prevented drastic loss of body weight and reduced food and water consumption in diabetic rats. Blood glucose, TC, TG, LDL-c, and MDA were also reduced and HDL-c, GSH, and CAT and SOD activity increased after administration of the extract of T. dodoneifolius (250 and 500 mg/kg) in diabetic rats. At the end of this work, it appears that the aqueous extract of the leaves of T. dodoneifolius has anti-diabetic, lipid-lowering, and antioxidant properties, thus supporting the use of this plant by traditional healers for the treatment of diabetes and some of its complications.
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