National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Hepatitis B virus (HBV) infection is a major health problem worldwide. Several mutations at the BCP region of HBV have been recently associated with an increased risk of HCC, and thus can serve as useful biomarkers for predicting the clinical outcome of chronic HBV patients. Genome sequencing of the BCP region of the HBV, in 80 chronically HBV infected patients (40 of whom had developed HCC), was performed in this study to identify the presence of mutations and to clarify whether any of these mutations could be considered as a biomarker for early detection of HCC in Egyptian patients. We found that T1753V and A1762T mutations were found in 22.5% and 20% of HCC group with significant difference versus non HCC group, while double mutations A1762T, G1764A were only found in a small percentage (5%) of HCC group. It could be concluded that the T1753V and the A1762T mutations, but not A1762T, G1764A, are strongly associated with development of HCC in chronic HBV Egyptian patients and could be used as valuable markers for early detection of HCC.
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