National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Aminoglycosides are antibiotics, often used in veterinary and human medicine for treatment of various infections caused by gram negative and some gram positive micro-organisms. Due to its inherent property of being refractory to most aminoglycoside modifying enzymes. Amikacin has been successfully used to treat the life threatening antimicrobial resistant infections. These antibiotics is their relatively low therapeutic index. The use at therapeutic doses may lead to adverse changes in haemato-biochemical parameters, especially with those connected with kidney and liver function. The aim of the present study was to determine the changes in some haemato-biochemical parameters on 1st, 3rd, 5th and 7th days after intramuscular administration with amikacin at therapeutic dose @10 mg/kg bwt for 5days in four healthy non lactating female goats. The results of present studies indicated that in healthy goats, at therapeutic doses of amikacin caused significant (p < 0.05) rise in serum BUN and creatinine level, but no significant (p < 0.05) changed observed in blood Hb, PCV, TLC, lymphocytes, monocytes, eosinophils, basophil and neutrophils and the serum albumin, globulin, total protein, bilirubin, cholesterol and triglyceride level during the experiment. Amikacin also caused significant (p < 0.05) rise in serum enzyme ALT, AST and ALP level. On the whole, the results of these studies demonstrate that amikacin have potential for altering biochemical and haematological values in female goats after using amikacin at therapeutic doses.
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