National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The ameliorative potential of Tinospora cordifolia (TC) and vitamin C (Vit. C) was studied against oxidative stress induced cardiotoxicity by cisplatin. 36 male Wistar rats were divided into 6 groups(n = 6). Group 1 was maintained as Normal control. Cisplatin (7.5 mg/kg B.W) was administered intraperitoneally to the groups 2, 5 and 6 on day 1. Groups 3 and 4 were administered for 14 days (p/o) with aqueous leaf extract of TC (400 mg/kg B.W) and vitamin C (100 mg/kg B.W), respectively from day 1. Group 5 and 6 received aqueous leaf extract of TC (400 mg/kg B.W)and vitamin C(100 mg/kg B.W), respectively for 14 days orally starting from the 1st day of cisplatin injection. Body weights, antioxidant parameters and cytokine profile were assessed. The present study revealed a significant (P < 0.05) increase in TBARS, protein carbonyls, TNF-alpha and IL-10, while significant (P < 0.05) decrease in GSH in group 2 compared to group 1. The groups 5 and 6 showed significant improvement in all the parameters in comparison to group 2.In conclusion beneficial effects of TC and vitamin C could be attributed to their antioxidant and immunomodulatory actions.
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