National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Zebrafish is the suitable model organism for identification of diseases which have same patho-physiology as in humans. A Zebrafish larva absorbs small drug molecules diluted in the surrounding water through their skin and gills hence drug administration is simple as compare to other experimental animals. Yolk sac, sinus venosus or circulation are also act as route of drug administration for the highly hydrophobic compounds, large molecules and proteins. Zebrafish can be used for each assay and small amounts of drug are required as compared to testing in other animal models. Due to transparency of zebrafish for several days’ post-fertilization enables in-vivo observation of live or whole mount fixed specimens including the visualization of vital dyes fluorescent tracers, antibodies and riboprobes. Organization of Economic Co-operation and Development (OECD) recommend zebrafish for aquatic toxicity testing. For the assessment of environmental toxicity agents fish have been used for years. Zebrafish have become a smart vertebrate model for toxicological testing. This is much faster, cheaper and more efficient animal model. Its biology has been shown to be highly similar to that of mammals.
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