National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The emergence and spread of antibiotic resistance, as well as the evolution of new strains of disease causing agents, are of great concern to the global health community. According to the European Centre for Disease Prevention and Control, MDR is defined as insusceptibility to at least one agent in three or more of the specified antimicrobial categories used in treatment. Since an effective treatment should be administered as soon as possible, resistance to many antimicrobial classes reduces the probability of adequate empirical coverage, with unfavorable consequences. In this study to investigate the phenotypic and genotypic characteristics of multidrug resistant Enterobacteriaceae in Mansoura Gastrointestinal Surgery Center, Egypt. A total of 99 multidrug resistant Enterobactericea isolates were included in this study. Antibiotic susceptibility testing using Vitek 2 system was done .Subsequent detection of different β-lactam and carpabenem resistance genes was done using conventional PCR method. 99 MDR isolates were selected from 641gram negative bacterial samples depending upon that the isolates were non susceptible to ≥ 1 agents in >3 antimicrobial categories. The most frequent isolated organisms were Klebsiella pneumoniae 27 (27.3%). The distribution of resistant genes was 19 for TEM gene, 17 for SHV and OXA-23, 15 for VIM gene, and 4for IMP in the 99 isolate.
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