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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(9): 277-285
DOI: https://doi.org/10.20546/ijcmas.2020.909.035


Molecular and Biological Characterization of a Vaccine – Derived Avian Avulavirus Type 1 Isolated from an Unvaccinated Goose
Deepthi1*, D. Ratnamma2, R. N. Ramani Pushpa1, Shrikrishna Isloor2, B. M. Veeregowda2 and M. L. Satyanarayana3
1Department of Veterinary Microbiology, NTR College of Veterinary Science,
Gannavaram, Andhra Pradesh, India, 521102
2Department of Veterinary Microbiology, 3Department of Veterinary Pathology, Veterinary College, Bangalore, India, 560032
*Corresponding author
Abstract:

ND is one of the most devastating diseases of the poultry industry. The disease was categorized as ‘notifiable’ owing to the immense economic losses caused to the poultry farmers. Wide host range is one major limiting factor in controlling the disease. While chicken, turkeys, doves, pigeons are highly susceptible, waterfowls such as ducks and geese are less susceptible and considered as natural reservoirs for lentogenic AAvV-1. We isolated an AAvV-1 strain from a goose raised in a mixed species poultry farm. Full length fusion gene sequence confirmed that the isolate belongs to genotype II of class II AAvV-1. Phylogenetic studies grouped the isolate with vaccine strain, Komarov. Twenty one day old chicken inoculated with this isolate were apparently healthy without any clinical signs. Minimal upregulation of proinflammatory, chemokine and apoptic cytokine levels was observed in the spleen of infected chicken. This study paved way for isolation of a low pathogenic strain of AAvV-1 from an apparently healthy water fowl. Further research is needed to evaluate the isolate as a vaccine candidate.


Keywords: Avian avulavirus, Waterfowl, Fusion protein, Pathogenicity, Cytokines
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How to cite this article:

Deepthi, B., D. Ratnamma, R. N. Ramani Pushpa, Shrikrishna Isloor, B. M. Veeregowda and Satyanarayana, M. L. 2020. Molecular and Biological Characterization of a Vaccine – Derived Avian Avulavirus Type 1 Isolated from an Unvaccinated Goose.Int.J.Curr.Microbiol.App.Sci. 9(9): 277-285. doi: https://doi.org/10.20546/ijcmas.2020.909.035