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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(9): 251-257
DOI: https://doi.org/10.20546/ijcmas.2020.909.031


Radon: The Hidden Killer
Tirthankar Dalui* and Ankita Mondal
Department of Zoology, Barasat Govt. College, Kolkata-700126, India
*Corresponding author
Abstract:

Radon (Rn) is a naturally occurring radioactive gas in rocks and soils. The long radioactive decay of uranium forms radon. Radon decays to form radioactive particles that may enter the body through inhalation. Daughter products of radon release high energy alpha particles associated with gamma  rays when radon undergoes radioactive decay. It is the second most common cause of lung cancer after smoking. When inhaled with radon gas, high energy ionizing alpha particles are produced from the 222Rn decay. Some of these alpha particles will interfere with biological tissue in the lungs resulting in weakened of cell’s DNA. Everyone is, to some extent, exposed to radon. Cracks in solid floors and under walls, gaps in suspended concrete and wooden floors and round pipe works and crack space, cavities in walls, building joints and small cracks or pores in hollow walls, can lead to radon entry into the building. The genotoxicity of radon gas is addressed primarily to bronchial epithelial and lung parenchyma. Radon comes into the body via the respiratory system. Therefore, the main target of its toxic effects is lung cells, where further decay occurs by emitting ionizing radiation, causing oxidative damage to DNA, proteins, and lipids. Accumulation of such damages in a cell, contribute to malignant transformation. The epigenetic basis of lung cancer is related primarily to changes in the profile of microRNA (miRNA). Lung damage associated with radon exposure was attributed to disturbances in miRNA and subsequent protein expression.


Keywords: Radon, Radioactive, Lung cancer, MicroRNA, Genotoxicity
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How to cite this article:

Tirthankar Dalui and Ankita Mondal. 2020. Radon: The Hidden Killer.Int.J.Curr.Microbiol.App.Sci. 9(9): 251-257. doi: https://doi.org/10.20546/ijcmas.2020.909.031