National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The present study was designed to evaluate the role of umbelliferone in alleviating hyperlipidemia and oxidative damage in streptozotocin induced diabetes mellitus in wistar albino rats. Six groups of rats were used as control, diabetic control, umbelliferone at 20 mg/kg b.wt., umbelliferone at 40 mg/kg b.wt. and combination of glibenclamide and umbelliferone at 20 mg/kg b. wt., was used in the study. Diabetes was induced in male Wistar rats by administering streptozocin at 45 mg/kg b. wt. in citrate buffer, intraperitoneally. Serum estimation of triglyceride and cholesterol as well as anti-oxidant profile such as SOD, CAT and GPx was evaluated on 15th, 30th and 45th day of experiment. The control rats showed normal values throughout the experimental period. The diabetic rats showed significant hypercholesterolemia and hypertriglyceridemia with reduced tissue anti-oxidant levels. Whereas, the umbelliferone treated groups showed significant decrease in triglyceride and cholesterol levels as well as increased the anti-oxidant profiles by the end of the experimental period. Thus, our results show that umbelliferone alone (20mg/kg. b. wt. and 40mg/kg. b. wt.) possessed anticholesterolemic and anti-triglyceridemic properties. The significant improvement in anti-oxidant profile in the current study could be attributed to bioactivity of umbelliferone and were statistically comparable with the glibenclamide treated group.
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