National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The study was undertaken for 150 days on female Sprague-Dawley rats to evaluate antioxidant effects on DMBA induced mammary tumours. A total of 80 rats were randomly allotted to 5 groups with 18 rats in 4 groups and 12 rats to the control group distributed to DMBA, DMBA + Tamoxifen and DMBA + Idivallathi mezhugu (IM) and IM groups. Rats were administered with 4 weekly doses of 5 mg DMBA/rat in olive oil by oral gavage beginning at 42nd day of age. From the day of first dosing of DMBA, tamoxifen (100 µg/kg/ BW/Day) was given in gingelly oil to DMBA + Tamoxifen group and IM (300 mg/kg BW/daily) in palm jaggery to DMBA+IM and IM groups by oral gavage till the end of study. DMBA group showed significant (P<0.05) increase in lipid peroxidation and antioxidants catalase (CAT) and superoxide dismutase (SOD) levels besides reduced glutathione (GSH). Whereas, IM and tamoxifen treated groups did not show any significant difference in lipid peroxidation and oxidative stress with no increase in the antioxidant level compared to the control. Selective growth advantage of tumour cells over their surrounding normal counterpart was evident in the DMBA group and inhibited lipid peroxidation and oxidative stress was evident in the IM group.
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