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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(6): 4222-4231
DOI: https://doi.org/10.20546/ijcmas.2020.906.495


Disposition Kinetics of Ivermectin (Ivomec Super®) Following Single Dose Subcutaneous Administration in Cattle Calves
S. Sakthikarthikeyan*, A. H. Ahmad and K. Kannan
Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, G.B.P.U.A & T, Pantnagar-263145 (Uttarakhand), India
*Corresponding author
Abstract:

The present study was undertaken to evaluate the pharmacokinetics of Ivermectin (Ivomec super®) 0.2 mg/kg b.wt in cattle calves.   The study was conducted in four cross-bred male cattle calves (1.0-1.5 yrs in age, weighing 110±5 kg). The plasma concentration of ivermectin was determined by HPLC. The decay in plasma concentration of drug was biexponential in cattle calves. The Cmax value of 33.38 ng/mL was obtained at Tmax of 4.49 days in cattle calves, following SC administration of Ivomec super ®. The elimination half life (β_HL), volume of distribution (V1_F) and AUC were calculated as 24.59 days, 2.28 L.kg-1, 393.9  day.ng/mL in cattle calves , following SC administration of Ivomec super ®. A dosage regimen of 0.2 mg/kg at 14 days interval is recommended in cattle.


Keywords: Cattle calf, Ivermectin, Pharmacokinetics, Subcutaneous
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How to cite this article:

Sakthikarthikeyan, S., A. H. Ahmad and Kannan, K. 2020. Disposition Kinetics of Ivermectin (Ivomec Super®) Following Single Dose Subcutaneous Administration in Cattle Calves.Int.J.Curr.Microbiol.App.Sci. 9(6): 4222-4231. doi: https://doi.org/10.20546/ijcmas.2020.906.495