National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Hepatitis C virus (HCV) infects many people worldwide and it is a leading cause of cirrhosis and hepatocellular carcinoma. Natural Killer (NK) cells have an important role during HCV infection as a part of innate immune responses. Three subtypes of NK cells are recognized: CD56dim CD16+ve, CD56bright CD16+ve and CD56–veCD16+ve. Natural killers T (NKT) (CD3CD16CD56+ve) cells are subsets of T lymphocytes that help in innate immune response because they can be directly cytotoxic. Our study was performed to investigate the role of NK cells and NKT cells in the pathogenesis of HCV infection. Our study was conducted on 30 adult patients (18 males and 12 females) with chronic HCV infections. All patients were seropositive for HCV antibodies and positive for HCV-RNA. Anti– CD56, Anti– Cd3, and Anti–perforine labeled monoclonal antibodies were used for flow cytometry. There was a significant reduction in the frequency and function of the NK cells (CD3- and CD56+) coincided with a quantitative imbalance of the CD56bright and CD56dim Subsets within the total NK population. Also, there was a shift in NK subsets dim into bright with a marked decrease in the CD56dim cell fraction as compared to CD56bright cells. A decrease in the frequency and function of the NKT cells (CD3+ and CD56+) in the peripheral blood of chronic HCV infected patients, compared to healthy controls, was observed. NK and NKT cells play important roles in the pathogenesis of chronic hepatitis C virus infection.
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