National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Present study was conducted for pharmacokinetic interaction of long acting moxofloxacin (LA moxifloxacin) with meloxicam at the dose rate of 7.5 mg.kg-1 and 0.5 mg.kg-1 respectively following intramuscular (IM) administration. Peak plasma concentrations of drug were estimated by using HPLC florescence detector. The values of different pharmacokinetic parameter of long acting moxifloxacin along with viz., b and t1/2b were found to be 0.058 ± 0.004 h-1 and 12.297 ± 0.843 h. respectively. The mean value of Cmax was 1.56 mg.ml-1 and Tmax was 1.5 h. The average value for AUC and AUMC was 18.53 ± 0.754 mg.h.ml-1 and 251.183 ± 20.501 mg.h2.ml-1. The value of mean residence time (MRT) was 13.467 ± 0.726 h. The mean values of Vd(area) and Vd(ss) were 7.249 ± 0.645 and L.kg-1, respectively. The mean value for total body clearance (ClB) was 0. 408 ± 0.01 L.h-1.kg-1. Present investigation revealed that meloxicam interacts with Long Acting moxifloxacin.
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