National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Enterobacteriaceae cause protean infections and are the common Gram negative isolates in a microbiology laboratory. Spectrum of multi-drug resistance includes AmpC, Extended spectrum beta lactamase and carbapenemase production with others. This was a cross sectional study to determine susceptibility pattern of AmpC and extended spectrum beta lactamase producing isolates against different antimicrobials. There was significant difference between the pure AmpC producing, pure ESBL producing, AmpC ESBL co-producing and AmpC ESBL non-producing isolates of E. coli, Klebsiella spp. and P. mirabilis regarding the resistance pattern against amoxycillin-clavulanate, piperacillin-tazobactam and co-trimoxazole for which the higher number of pure AmpC producers or AmpC ESBL co-producers were found to be resistant as compared to pure ESBL producers. In addition, there was significant difference in the resistance pattern against imipenem and chloramphenicol among pure AmpC producing, pure ESBL producing, AmpC ESBL co-producing and AmpC ESBL non-producing isolates of E. coli, sulfonamide in case of Klebsiella spp and imipenem in case of P. mirabilis isolates. The difference can be justified by the fact that the AmpC producers are not inhibited by the beta lactamase inhibitors like clavulanic acid.
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