International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 9, Issue:3, March, 2020

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(3): 1121-1132

A Bacteriological Study of Neonatal Septicaemia
Pradnya Naik1* and Vishwanath Sannayya2
1Department of Microbiology, Goa Medical College, Bambolim ,  Goa  403202, India
2Health Quest Diagnostics, Panjim, Goa- 403001, India
*Corresponding author

Neonatal sepsis is defined as a bacterial infection of the blood in an infant younger than 4 weeks of age. Blood cultures remain the mainstay of laboratory diagnosis of bloodstream infections (BSIs) in infants. The knowledge of bacteriological profile and its antibiotic sensitivity patterns is of immense help in saving lives of neonates with septicaemia. The study was conducted on neonatal blood samples to identify the common pathogens as well as rare and newer pathogenic species causing neonatal septicaemia along with their antibiotic sensitivity to help formulate guidelines for empiric antibiotic therapy in a developing country. A  retrospective  study was carried  out on neonatal  septicaemia for a  period  of  two  years from 2018 to 2019 on total 746 blood samples of neonates from konkan region at  a private  Microbiology lab in North Goa. Blood samples were processed for identification of pathogens along with antibiotic sensitivity by BACTEC and VITEK automated machines. Out of the 746 blood samples received 77 (10.3 %) samples showed growth of pathogenic organisms. 65 isolates were gram negative and 12 were gram positive. Amongstgram negative organisms Klebsiellapneumonia (28.6%) and Pseudomonas species (24.7%) were most commonly isolated and amongst the gram positive were CONS (5.2%) and MRSA (3.9%).Pandorea species and Ralstoniapickettii were the newer pathogens isolated. Gram negative organisms showed highest resistance to Beta lactamase inhibitors (86.7 %), Cephalosporins (75.6%)and Gentamicin (75.4%)and sensitivity to Carbapenemes and Colistin whereas gram positive organisms showed overall resistance to Beta lactam inhibitor Benzyl Penicillin (83.3%) and to Ciprofloxacin (66.7%) and sensitivity to Glycopeptides like Teicoplanin and Vancomycin. Resistance of common pathogens  to  multiple  antimicrobial  agents along with emergence of newer pathogens  is  a  great  challenge  to  the  effective  management  of  neonatal septicaemia, hence formulation  of  rational  antibiotic  policy  is important  to guide  the  clinicians  regarding  both  the  empirical  and  definitive treatment.

Keywords: neonatal infection , septicaemia, blood culture, konkan, BACTEC,  VITEC , antibiotic resistance

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How to cite this article:

Pradnya Naik and Vishwanath Sannayya. 2020. A Bacteriological Study of Neonatal Septicaemia. Int.J.Curr.Microbiol.App.Sci. 9(3): 1121-1132. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.