National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Diagnosis and management of patients with tuberculous pleuritis needs a rapid and sensitive diagnostic tool. Our aim was to diagnose cases of tuberculous pleuritis from patients employing ZN smear, culture (LJ & MGIT) and to compare with PCR. Pleural fluid collected from 36 patients with clinical and/or radiological suspicion of TB pleuritis was included in this study. Pleural fluid collected from nine non-tuberculous pleuritis cases was included as negative controls. Pleural fluid samples were analyzed for ZN smear, LJ and automated MGIT culture and results compared with MTB PCR targeting IS6110 region. Positivity for smear, LJ, MGIT and PCR individually were 5.6%, 2.8%, 16.7% and 25% respectively. Combination of all above techniques together increased the percentage positivity to 30.6%. Negative controls were negative by all procedures. In the context of paucibacillary specimens like pleural fluid, smear microscopy and LJ are less sensitive. MGIT has moderate sensitivity and rapidity compared to LJ. PCR is rapid and highly sensitive, but needs interpretation of PCR reports with “gold standard” culture and clinical history to arrive at an early and accurate diagnosis.
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