National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The immune response against tuberculosis (TB) plays a fundamental role in the outcome of Mycobacterium tuberculosis (Mtb) and M. bovis (Mbs) infection. The host’s innate immune cells such as macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells interact with Mtb and Mbs. And as such express a variety of pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), Nod-like receptors (NLRs) and C-type lectin receptors (CLRs). All these receptors have been implicated in the recognition and uptake of Mtb and Mbs by various innate immune defense-associated cellular functions, such as phagocytosis, autophagy, apoptosis and inflammasome activation. In view of this, the present review article provides an updated overview and a better understanding of the cellular and molecular immune mechanisms underlying host-pathogen interactions that could provide a rational basis for the development of effective anti-TB therapeutics and diagnosis of the disease.
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