National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Phytobioactives have been proved to be effective on various ailments and diseases. The same logic is been used by many traditional healers and practitioners and is evident from ancient scripts of Ayurveda. One such, less explored plant is Anacardium occidentale L., (Anacardiaceae). The phenolics from the leaves and bark have been partially explored in folklore medicine but the probable mode of action is still unclear. Hence the current study aims at the exploration of the anti-cancer potency of phytobioactives from Anacardium occidentale. Qualitative phytochemical profiling of the leaves and bark, followed by polarity based hot extraction procedure (hexane, ethyl acetate, methanol), In vitro antioxidant studies (ABTS, nitric oxide, reducing power radical assays) and cytotoxic studies were performed on six cell lines (Vero, L929, A549, MCF 7, U87 and Hela). The probable mode of action on p38α MAP kinase was proposed based on In silico molecular docking structure-activity relationship (SAR) studies wherein partially purified fractions predominately contained zoapatanolide A (diterpenoid), a gas this flav one (biflavonoid) and anacardic acid (phenolic acid) were considered, out of which a gas this flav one had an atomic contact energy (ACE) values of -345.06 than compared to the standard drug doxorubicin (-409.14). The results of the current study inferred the potency of the herbal cocktail as antioxidant and being functional against cancer cell lines (ethyl acetate fraction). Further, studies could be extrapolated for the purification of the active ingredients from Anacardium occidentale in search for potent, newer therapeutics.
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