National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Most common bacterial agents of Lower Respiratory Tract Infection in the Intensive Care Units are Pseudomonas, Acinetobacter, Klebsiella, Citrobacter; which are multi drug resistant, and with limiting the therapeutic options.Nonfermenting Gram-negative bacilli are known to produce Extended spectrum β-lactamases (ESBLs) and metallo β-lactamases. Pseudomonas aeruginosa and Acinetobacter spp. in particular are most often associated with carbapenem resistance. The antimicrobial susceptibility testing of non-fermenting gram negative isolates was done by Kirby Bauer disc diffusion method according to CLSI 2019 (Clinical Laboratory Standards Institute) guidelines. Out of total 227gram negative isolates, nonfermenting gram negative bacteria were 118. out of 118, 76 were Pseudomonas aeruginosa and 42 were Acinetobacter baumannii. Out of total 76 isolated Pseudomonas aeruginosa, 33(43.42%) were resistant to imipenem and 22(28.94%) were resistant to meropenem. Out of total 42 isolated Acinetobacter baumannii,16(38.10%) were resistant to imipenem and 11(26.19%) were resistant to meropenem. In view of carbapenem resistance amongst the isolates, antibiotic therapy should be advocated or modified following culture and sensitivity. This would not only help in the proper treatment of the patient but also would discourage the indiscriminate use of available antibiotics and stop the spread of drug resistance bacteria.
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