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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here
ICV 2022: 95.28
Index Copernicus ICI Journals Master List 2022 - IJCMAS--ICV 2022: 95.28
For more details click here
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Original Research Articles                      Volume : 9, Issue:2, February, 2020
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38
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Int.J.Curr.Microbiol.App.Sci.2020.9(2): 1196-1204
DOI: https://doi.org/10.20546/ijcmas.2020.902.141


Effects of Fermentation Conditions on the Production of
Secondary Metabolites of Penicillium brevicaule alba-CC200 and
Aspergillus egypticus–HT166 Inhibiting Pancreatic α-Amylase
G. Gulyamova, D. M. Ruzieva, S. M. Nasmetova,
I. Muhammedov, G. A. Rasulova and R. S. Sattarova*
Department of Biochemistry and Biotechnology of Physiologically Active Compounds, Institute of Microbiology of the Academy of Sciences RU, Uzbekistan
*Corresponding author
Abstract:

Carbon and nitrogen sources were selected to create a new modified Chapek-Doks nutrient medium in order to increase the production of secondary metabolites, that inhibit pancreatic α-amylase, by endophytic fungi Penicilliumbrevicaule alba-CC200 and Aspergillus egypticus-HT166. The results showed that the highest α-amylase inhibitory activity - 96.8% and 88%, respectively, was observed during the shake flask cultivation of strains at the end of the stationary  phase on a medium containing  casein supplemented by yeast extract.


Keywords: Endophytic fungi, α-amylase, Inhibitory activity, Secondary metabolites

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How to cite this article:

Gulyamova, T. G., D. M. Ruzieva, S. M. Nasmetova, I. I. Muhammedov, G. A. Rasulova and Sattarova, R. S. 2020. Effects of Fermentation Conditions on the Production of Secondary Metabolites of Penicillium brevicaule alba-CC200 and Aspergillus egypticus–HT166 Inhibiting Pancreatic α-Amylase. Int.J.Curr.Microbiol.App.Sci. 9(2): 1196-1204. doi: https://doi.org/10.20546/ijcmas.2020.902.141
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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