Antibacterial susceptibility profiles of alum were determined against bacteria isolated from shellfish bivalve oysters. In-vitro bioassay using disc and agar well diffusion techniques with different concentrations; 1.5, 2.0, 2.5 and 3.0% of Alum were used to determine the susceptibility profiles of these isolates and compared with standard antibiotic, Ofloxacin (OFL) as control. Diameter of inhibition zones (DIZ) also were determined by measuring with a meter rule. Alum exhibited high levels of sensitivity on Proteus sp (18.0mm), Bacillus subtilis and Staphylococcus aureus (17.0mm) respectively, Escherichia coli and Klebsiella species (16.0mm) and Pseudomonas aeruginosa and Vibrio species (13.0mm) respectively. Its inhibitory potency on Gram negative and Gram positive bacteria suggests broad spectrum activity and can be used as a novel and emerging antimicrobial agent in food systems to combat the effects of some spoilage or biodeteriorative bacteria and foodborne pathogens. Ofloxacin’s highest sensitivity profiles to test bacterial isolates suggest broad spectrum antibiotic activity and underscore the fact it could be proficient as the drug of choice for management of patients following the consumption or outbreak of foodborne illness due to these bacterial pathogens.

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