National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Observation of normal or abnormal keratin forms is the major criteria in histopathological diagnosis of Verrucous carcinoma. The aim of the study is to evaluate and compare the distinct staining and surface keratin in verrucous carcinoma and normal keratinizing epithelium by routine hematoxylin and eosin (H&E) stain, modified papanicolou stain and modified Mallory’s stain. The known cases of verrucous carcinoma and tissues from normal keratinizing epithelial regions with sufficient paraffin embedded tissue were selected. The three sections from each block were stained with H&E stain, modified Papanicolou stain and modified Mallory’s stain. The modified Mallory’s stain, modified Papanicolou stain distinctively and clearly stained surface keratin compared to H&E stain. The positive staining of surface keratin was significantly associated with all stains at the level of p=0.001 in verrucous carcinoma and normal epithelium respectively. Based on our observation we conclude that the positive staining of surface keratin was significantly associated at p=0.001 in verrucous carcinoma and normal epithelium with all stains however the positivity was more associated with modified Papanicolou stain followed by modified Mallory stain least by heamatoxylin and eosin Stain. So, these special stains can be used as an adjuvant stain along with H&E stain.
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