National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Human cytomegalovirus (HCMV) is a prominent opportunistic infectious agent causes severe and fatal diseases in immune compromised individuals including patients undergoing hemodialysis. Although the impact of HCMV infection in general population and patients at particular health care institutions are well documented in several regions, the seroepidemiologic data and overall awareness of disease risk of HCMV infection remain largely poor in Libya. Therefore, this study was undertaken to derive chronic hemodialysis-based estimates of HCMV prevalence. A total of 102 subjects admitted to the hemodialysis unit at Nephrology Center of Benghazi/Libya were enrolled in this study and investigated for CMV IgM and IgG antibodies as well as CMV pp65 antigenemia tests. The overall seropositivity for IgG antibodies (% 26.47) was higher than those of IgM antibodies (% 21.56) and pp65 (% 17.64). CMV-IgG was detected in a higher rate in females than that in males (% 27.58% and % 26.02 respectively). Similarly, the seroprevalence of CMV-IgM were also much higher in females (% 48.27) than that in male patients (% 10.95). We also noticed a higher proportion of females were seropositive for CMV-pp65 (% 20.68) than males (% 16.43). However, there was no significant difference in the seroprevalence rates of CMV infection based on gender. According to age, a progressive increase in seropositivity of CMV was observed in all three tests performed on hemodialysis patients. However, the age groups were not significantly associated with CMV prevalence. In contrast, only 2 (% 1.96) patients were shown to be positive for all three performed assays indicating a recurrent infection. In addition to the clinical significance of our findings for the management of CMV infection in hemodialysis patients, CMV infections in this setting may also improve our understanding of the viral pathogenesis.
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