National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
1Department of Veterinary Pathology, College of Veterinary Science,Rajendranagar, Hyderabad-500030, India
2Department of Veterinary Pathology, College of Veterinary Science, Mamnoor-506166, India
3Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad-500030, India
The aim of this study was to determine the body weight changes and gross pathological alterations induced by glyphosate exposure in male albino Wistar rats and its amelioration with Ascorbic Acid. Forty eight (48) adult male albino Wistar rats were used for this study. The experiment was carried out for 21 days. The animals were randomized into 4 groups with twelve (12) animals in each. Group 1 - control, group 2 - GLP (@500 mg/kg b.wt), group 3 - AA (@250 mg/kg b.wt) and group 4 - GLP+AA (@500 mg/kg b.wt + 250mg/kg b.wt). The treatment regimens were administered by oral gavage once daily for three weeks. Individual body weights of all the rats were recorded soon after arrival and subsequently on 7th, 14th and 21st day of experiment to study the body weight gains. A significant (P<0.05) reduction in the body weights were recorded in glyphosate treated rats compared to the control rats. On necropsy examination, severe congestion of liver, kidneys and testes and atrophy of kidneys and testicles were recorded in glyphosate treated rats.
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