National Academy of Agricultural Sciences (NAAS)
|
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Type III Interferons also known as Interferon lambdas (IFNï¬s/IFNLs) constitute a recently described IFN with antiviral activities by signaling through a unique receptor complex composed of IFNï¬s receptor 1 (IFNï¬R1) and interleukin-10 receptor 2 (IL10R2). It also found to have more of immune modulatory activities in addition to antiviral activities. In the present study, the construct pcDNA-bovine IFNλ3 was administered intramuscularly to mice. The mice were sacrificed on 7th and 14th day to collect the different organs/tissues. The tissues were used to isolate total RNA and following cDNA conversion. Then, the tissues were analyzed for the expression of IFNï¬ gene by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). The results had shown that there was expression of given IFNλ3 in organs: leg muscle, liver and spleen and also in blood.
Citations |
 |
 |
 |
 |
