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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:2, February, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(2): 511-522
DOI: http://dx.doi.org/10.20546/ijcmas.2016.502.058


Synthesis, Characterization and Polymerization of 1,3,4- Oxadiazole Derivatives of Amoxicillin and Evaluation Antibacterial Activities
Entesar, Obeed. AL-Tamimi1 and Khalida, Ali.Thejeel2*
1Department of Chemistry, College of Science, University of Baghdad, Iraq
2Department of Pharmaceutical Chemistry, College of Pharmacy, University of AL-Mustansriah, Iraq
*Corresponding author
Abstract:

A new series of 1,3,4-oxadiazoles, have been synthesized from amoxicillin on treatment with various chemicals, the prepared 1,3,4-oxadaizoles derivatives(9-13) reacted with acryloyl chloride to prepared acryl monomers (14-18) that polymerized to acryl polymers of amoxicillin derivatives (19-23). The structures of compounds (2-23) have been elucidated by FT-IR and 1HNMR, furthermore some compounds (9-13) and (19-23) were screened for in vitro antibacterial activity against gram positive and gram negative bacteria. The  compounds show inhibitory action against test organism


Keywords: Amoxicillin, Acryl monomers, Antibacterial activity.

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How to cite this article:

Entesar, Obeed. AL-Tamimi and Khalida, Ali.Thejeel. 2016. Synthesis, Characterization and Polymerization of 1,3,4- Oxadiazole Derivatives of Amoxicillin and Evaluation Antibacterial ActivitiesInt.J.Curr.Microbiol.App.Sci. 5(2): 511-522. doi: http://dx.doi.org/10.20546/ijcmas.2016.502.058
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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