National Academy of Agricultural Sciences (NAAS)
|
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Study was conducted on 84 adult male Wistar rats for a duration of sixty days. Animals were divided into twelve equal groups and treatments were applied as 2x3x2 factorial design with 2 renal conditions (Normal and Compromised); 3 cholesterol supplementation levels (0%, 0.5% and 1% w/w on DM basis) and 2 niacin supplementation levels (Unsupplemented and Supplemented @ 100 mg/kg body weight per day orally). Renal dysfunction was induced in respective groups by daily intra-peritoneal injection of gentamicin @ 80mg/kg body weight for 8 days. Blood samples were collected on 0th, 20th, 40th and 60th day of experiment to study lipid profile. Renal dysfunction as well as cholesterol supplementation resulted in significant (p<0.01) elevation of total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL-c), very low density lipoprotein (VLDL-c) and a significant lowering of high density lipoprotein (HDL-c) levels. Niacin Supplementation @ 100 mg/kg body weight, however led to significant improvement in lipid profile.
Citations |
 |
 |
 |
 |
