Maternal infections caused by TORCH [Toxoplasma gondii, Rubella virus, Cytomegalovirus (CMV), Herpes simplex virus (HSV)] are the major causes of bad obstetric history. The aim of this study was to evaluate the age wise seroprevalence and to assess the seropositivity of Toxoplasma and Rubella among TORCH infections in pregnant women with BOH. A total of 90 sera samples are collected from pregnant women with bad obstetrical history attending the antenatal clinic in Govt. Maternity Hospital, Sultan Bazar, Kothi, Hyderabad. Patients included in this study were those with history of stillbirths, habitual abortions, intrauterine growth retardation and neonatal deaths. Serological analysis of Toxoplasma and Rubella among TORCH infections by IgM and IgG was carried out at Regional STD laboratory of Osmania General Hospital, Hyderabad. In the present study it was found that the prevalence of TORCH infection was more common in 19 - 24 years - 51 (56.7%). Total study population majority of the pregnant females had previous history of two or more spontaneous abortions 63 (70%) followed by intrauterine deaths 40 (44.4%). Among these patients 11 (12.2%) had history of both spontaneous abortions and intrauterine deaths. Of the 90 BOH cases, serological evidence for any one of the TORCH agents was detected in 80 (88.8%) pregnant females. Seronegativity to IgM/IgG was observed in ten cases (11.1%). The IgM / IgG antibody positivity to Toxoplasma gondii 5 (5.6%) / 28 (31.1%), Rubella 8 (8.9%) / 48 (53.3%). In the present study out of 90 antenatal women with BOH 28 (31.1%), were seropositive for Toxoplasma specific IgG, 5 (5.6%) cases were seropositive for Toxoplasma specific IgM antibodies and 1 case (1.1%) was seropositive for both IgG and IgM. Majority of seropositive Toxoplasma and Rubella cases were seen in the age group 19 - 24 years. In the present study Toxoplasma gondii, which is a known etiological agent in recurrent pregnancy wastage was found positive in 28 (31.1%) IgG and 5 (5.6%) IgM pregnant women with BOH [18 (20%)]. Overall seropositivity of Rubella concluded in this study is 56 (63%). Out of these 56 cases of BOH 34 had a history of two or more spontaneous abortions while 21 of them had a history of intrauterine deaths and one case had a history of congenital malformation. In the present study, of the 90 cases of BOH the seropositivities of the pregnant women for anti-rubella IgM is 8 (8.9%), while IgG is 48 (53.3%). Of these Rubella seropositive females 6 (6.7%) were positive for both IgG & IgM. The present study demonstrates a strong association between the TORCH infectious agents and women having BOH. All the patients with previous history of recurrent pregnancy miscarriage should be subjected to TORCH screening. All antenatal cases with BOH, should be routinely screened for TORCH agents as early diagnosis to reduce adverse fetal outcome, diminishing the morbidity and mortality.

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