National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Many plants in Africa are medicinal. The use of medicinal natural plants predates the establishment of antibiotics and other modern drugs into the African continent. The antibacterial activity of Gongronema latifolium and a synthetic antibiotic (Rocephin) on a clinical isolate of Staphylococcus aureus was evaluated in vivo using albino Wister rats. Five (5) adult female rats with weight ranging from 120 – 180 kg were purchased, housed, fed and nurtured for five days. Four (4) of the rats were inoculated with 0.1 ml 4hour growing broth culture of Staphylococcus aureus. Blood was collected from the rats prior, during and after inoculation and treatment for haematological analysis and bacteraemia. Treatment was done by administering 0.5ml of Rocephin (equivalent to 0.125mg) to rat 1 and 0.5ml of purified ethanolic plant extract (equivalent to 0.5mg) to rat 2, A combination of both preparations as above was administered to rat 3. Rat 4 was not given any treatment. Results indicated that the extract of G. latifolium leaves possesses higher antibacterial activity than the antibiotic Rocephin and the combination therapy. This result has shown the relative potency of G. latifolium against Staphylococcus aureus bacteria in vivo.
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