National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Graded Spl (Microbiology), Department of Pathology, Command Hospital, Pune-411040, India
Urinary tract infections (UTIs) are the most common bacterial infections encountered in clinical practice, which cause morbidity in both hospitalized and out patients. Increasing antimicrobial resistance among bacterial uropathogens is a significant health concern. To determine spectrum of microorganisms responsible for UTIs and their antimicrobial resistance pattern. Urine samples received in microbiology laboratory for culture from 17,135 patients clinically suspected of having urinary tract infection during the study period were processed according to standard protocol. Isolates were identified by conventional phenotypic methods and antibiotic resistance determined by Kirby Bauer disc diffusion method and Clinical and Laboratory Standards Institute (CLSI) guidelines. Out of 17,135 urine samples, 2731 (15.9%) were considered as positive growth, which yielded 2760 isolates. The most common isolate was Escherichia coli (60.9%) followed by Klebsiella pneumoniae (14.6%), Pseudomonas aeruginosa (5.6%), Enterococcus spp. (4.8%), Staphylococcus aureus (4.2%), Staphylococcus saprophyticus (3.0%), Acinetobacter baumannii (2.9%), Proteus spp. (2.6%) and others (1.4%). Most of the Gram-negative isolates showed resistance to fluoroquinolones, cephalosporins and aminoglycosides, whereas most Gram-positive isolates were found to be resistant to penicillins, co-trimoxazole and fluoroquinolones. Nitrofurantoin was the only drug which exhibited good sensitivity against both Gram-negative as well as Gram-positive isolates. E. coli and K. pneumoniae are the most common uropathogens. Nirofurantoin can be used for effective treatment as an emperical therapy for UTIs in OPD patients. Carbapenems and colistin should be reserved for complicated UTIs and prescribed only after sensitivity reports are available.
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