National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Rheumatoid arthritis is a chronic systemic inflammatory autoimmune disease primarily characterized by a bilateral symmetrical polyarticular arthritis, which is often erosive.The last 5 years have seen the emergence and establishment of antibodies to citrullinated antigens as the diagnostic marker for rheumatoid arthritis (RA). Initially, these were detected using a synthetic peptide, which has undergone a number of modifications to give a diagnostic test with a sensitivity of 65–80% and a specificity of >95%. Antibodies to citrullinated vimentin were first described in 1994 as a highly specific marker for RA (anti-Sa). However, no easily performed assay for these antibodies has been available. Among them, antibodies against cyclic citrullinated peptides (CCP) are useful for diagnosing RA. antibodies to mutated citrullinated vimentin (MCV) were described recently in RA. The aim of this study was to determine the diagnostic values of ACCP compared to anti-MCV in rheumatoid arthritis patients. This study included 92 patients with Rheumatoid arthritis (RA) an 35 matching healthy controls. Blood samples were obtained from patients and controls for erythrocyte sedimentation rate (ESR),C reactive protein (CRP), rheumatoid factor (RF). Anti-CCP2 and anti-MCV were determined using ELISA technique. RA group was significantly higher than control group as regard ESR, CRP, RF, Anti-CCP, and Anti- MCV. It was concluded, compared to ACCP, anti-MCV has approximately the same accuracy for the diagnosis of rheumatoid arthritis.
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