National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The aim of the present study is to identify the presence of Epestein Barr virus (EBV), Human Herpes virus 6 (HHV6)and Human Herpes virus 7 (HHV7) by molecular methods in newly diagnosed ALL in children and to correlate their presence with clinical and immunophenotypes of ALL. The present study included 60 children at the time of diagnosis of ALL before start of the therapy and 60 healthy cross match age and sex children as a control group. The study of EBV, HHC6 and HHV7 was carried out by real time polymerase chain reaction (PCR). In comparison between the prevalence of EBV, HHV6, HHV7 between patients and control there was statistically significant increase in prevalence rates (31.7 versus 1.7 for EBV, 16.7% versus 3.3% for HHV6 and 13.3% versus 8.3% for HHV7 respectively, P=0.0001). Moreover, the mean± SD copies/ml was statistically significant higher for HHV6 in patients compared to the controls (P=0.0001). There was significant association between EBV and HHV6 infection in patients (P=0.001). In EBV+ ALL, there was significant higher rates of hepatosplenomegaly (47.4%, P=0.01) In conclusion, EBV, HHV6 and HHV7 viruses were present in high rates in ALL which suggest a role for these viruses in pathogenesis of ALL. Further studies are required to validate this hypothesis.
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