National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Extended spectrum β-lactamases are often plasmid mediated and derived from mutations in bla-TEM, bla-SHV, bla-CTX-M, and bla-AmpC genes by one or more amino acid substitution around the active site. These genes are responsible for resistance to beta lactams in Pseudomonas aeruginosa. In this study, Pseudomonas aeruginosa were isolated from wound and burn infection patients admitted to Diwanyia Teaching Hospital. Routine microbiological methods were used then PCR technique for the detection of four extended spectrum β-lactamases genes (bla-TEM, bla-SHV, bla-CTX-M, and bla-AmpC). The PCR results indicated high prevalence of Extended-spectrum β-lactamases in burn infections (bla-TEM (66.7%), bla-SHV (86.7%), bla-CTX-M (93.3%), and bla-AmpC C (53.3%) and less prevalent in wound infections infected with Pseudomonas aeruginosa (bla-TEM (59.1%), bla-SHV (68.2%), bla-CTX-M(81.8%), and bla-AmpC (50%). In conclusion, Pseudomonas aeruginosa isolates of wound and burn infection patients are highly associated with emergence of extended spectrum β-lactamases genes that provide antibacterial resistance to almost broad spectrum antibiotics.
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