Blood stream infections (BSI) in patients admitted to Intensive care unit (ICU) has a high fatality rate as these patients also have associated comorbid conditions. One of the life saving invasive procedures includes the central line which introduces infection and makes them more vulnerable to BSI. Laboratory processing of Central line to detect such infections becomes mainstay to differentiate infection from colonization. Infection with multi drug resistant organisms (MDRs)is on rise and treating such highly resistant organism faces a great challenge to the treating clinician.  To assess the microorganisms causing such infection related to central line and perform their Antimicrobial susceptibility testing. Processing of central line catheters with relevant clinical samples was done under proper aseptic techniques.  Among study population, 47(21.36%) patients developed central line related local infection and 7 (3.18%) patients developed central line associated blood stream infection (CLABSI). Gram negative isolates (71.42%), Gram positive isolates (14.28%), and Candida albicans (14.28%) were common isolates from CLABSI. Gram negative isolates were predominant in causing local and systemic infections related to catheter.

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