International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 7, Issue:10, October, 2018

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(10): 161-182

Effects of Antibiotic Withdrawal on Multidrug Resistant Escherichia coli
Hitesh Kumar* and Sunil Maherchandani
Department of veterinary Microbiology, CVAS, Bikaner (Raj.), India
*Corresponding author

Antimicrobial resistance (AMR) is an increasingly serious threat to global public health. The increase in antibiotic consumption is well evident which accelerates the AMR. The continuous dissemination of ‘multidrug-resistant’ (MDR) bacteria drastically reduces the efficacy of antibiotics and consequently increases the frequency of therapeutic failure. In MDR bacteria the over-expression of efflux pumps that expels antibiotics which contribute to the increased resistance by decreasing the intracellular concentration of antibiotics. In the present study 42 MDR isolates from different groups (human, pig, and poultry) were evaluated for their antibiogram profile, mechanism of antibiotic resistance prevalent in them and to know the effects of withdrawal of antibiotics on bacterial resistance MDR bacteria were sub-culture. Withdrawal of antibiotic definitely helps in reverting the resistant phenotype in majority of the MDRs. The recent investigation on the AMR, including adaptive mechanism to resistance for various antibiotics, may pave the way towards the decreased frequency of emergence of Escherichia coli strains that are highly resistant.

Keywords: Multidrug-resistance, Efflux activity, Efflux pumps, Antibiotic withdrawal

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How to cite this article:

Hitesh Kumar and Sunil Maherchandani. 2018. Effects of Antibiotic Withdrawal on Multidrug Resistant Escherichia coli.Int.J.Curr.Microbiol.App.Sci. 7(10): 161-182. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.