National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Antimicrobial resistance (AMR) is an increasingly serious threat to global public health. The increase in antibiotic consumption is well evident which accelerates the AMR. The continuous dissemination of ‘multidrug-resistant’ (MDR) bacteria drastically reduces the efficacy of antibiotics and consequently increases the frequency of therapeutic failure. In MDR bacteria the over-expression of efflux pumps that expels antibiotics which contribute to the increased resistance by decreasing the intracellular concentration of antibiotics. In the present study 42 MDR isolates from different groups (human, pig, and poultry) were evaluated for their antibiogram profile, mechanism of antibiotic resistance prevalent in them and to know the effects of withdrawal of antibiotics on bacterial resistance MDR bacteria were sub-culture. Withdrawal of antibiotic definitely helps in reverting the resistant phenotype in majority of the MDRs. The recent investigation on the AMR, including adaptive mechanism to resistance for various antibiotics, may pave the way towards the decreased frequency of emergence of Escherichia coli strains that are highly resistant.
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