Thyroid diseases are common in the general population and usually presented as thyroid nodules. Most nodules are benign while thyroid cancer represents 5-24% of cases. Thyroid carcinoma is classified into PTC, FTC, ATC, and MTC. The aim of this study was to assess the role of morphometric study in the differentiation between benign and malignant thyroid lesions. Nuclear morphometry measurement was carried out on 90 different thyroid lesions (40 benign and 50 malignant). Morphometry was performed using 3 parameters (mean nuclear area, nuclear perimeter and maximal nuclear diameter). All 3 measured parameters were statistically significant as they were much higher in malignant lesions than benign lesions. Also, statistically significant correlation was found between follicular adenoma, FVPTC and follicular carcinoma. In benign lesions, Granulomatous thyroiditis had the lowest nuclear morphometric parameters while Hurthle cell adenoma had the highest parameters. Inn malignant tumors, PDTC and medullary carcinoma had the lowest measured parameters while anaplastic thyroid carcinoma had the highest. Nuclear morphometric measurements can aid in the differentiation between benign and malignant thyroid lesions especially follicular patterned lesions.

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