National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The experimental work was undertaken to study the therapeutic efficacy of aqueous, alcoholic and biherbal extracts of Vigna unguiculata (V.U.) and Hordeum vulgare (H.V.) on ethyleneglycol and ammonium choride induced urolithiasis in female wistar rats. Rats were dividedinto1 4groups. Each of 6 rats except lithiatic control group consist 8 rats. Group I and II served as lithiatic and vehicle control, respectively. In group I and III to XIV induction of urolithiasis was done by administration of 0.75 % (v/v) ethylene glycol and 2% (w/v) ammonium chloride along with drinking water for 28 days. Group II was given 0.5% sodium bicarbonate. After 28th day, the rats of urolithiatic treatment Groups III to XIV were given aqueous and alcoholic seed extract of V.U. and H.V. @ 200 mg/kg and 300 mg/kg bwt orally as either single extracts or combination as biherbal extracts (1:1) in 0.5 % sodium bicarbonate using syringe and rat gavage needle. Blood samples were collected. Confirmation of urolithiasis was done by evaluating serum biochemical parameters. However, increase level of serum glutamic-pyruvic transaminase, Blood Urea Nitrogen, uric acid, creatinine, calcium and phosphorus, while decreased level of serum total protein and serum magnesium were observed in urolithiatic groups as compared to vehical control group on 28th day. Results of serum biochemistry reveals aqueous and alcoholic extract of V.U. and H.V. possess good therapeutic efficacy against urolithiasis. The effect of biherbal alcoholic extract of the seeds was much better in restoring the values on 63rd day after treatment.
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