National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Klebsiella pneumoniae, being prevalent in the nosocomial environment, is capable of expressing a variety of resistance enzymes, thus justifying their continued monitoring. The present study was undertaken to determine the prevalence of multi-drug resistant Klebsiella pneumoniae isolated from post surgical wound infection and to know their resistance pattern. Consecutive, non-repeat Klebsiella pneumoniae isolates obtained from post surgical wound infection were processed by conventional culture method and antimicrobial susceptibility test. ESBL, AmpC, MBL and KPC production was detected by Phenotypic confirmatory disk diffusion test, AmpC Disk test, Imipenem+EDTA Combined disk test and Modified Hodge Test respectively. Out of 84 pus samples, 67 (79.7%) were ESBL producers, 36 (42.8%) were AmpC producers and 12 (14.3%) were MBL producers. Thirty one (36.9%) Klebsiella pneumoniae isolates were both ESBL and AmpC co-producers whereas ESBL, AmpC and MBL co-producing isolates were 12 (14.3%). However none of the isolates were positive for Klebsiella pneumoniae Carbapenemase (KPC) by Modified Hodge Test. ESBL, AmpC and MBL positive isolates were more drug resistant compared to non-producers for all the antibiotics used in the study. Enhanced infection control, coupled with antibiotic stewardship programs, therefore play an important role in limiting the spread of this terrifying antimicrobial resistance.
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