National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Urosepsis is defined as presence of systemic inflammatory response syndrome secondary to a severe infection of the urinary tract, with the risk of multi-organ dysfunction and shock. This study was designed to analyze the antimicrobial susceptibility profile of E. coli isolates causing urosepsis and to compare it with the susceptibility profile of other isolates of E. coli from blood stream infection. And to study the various factors associated with E. coli urosepsis cases. A total of 689 isolates of E. coli were isolated from blood cultures in 2015. Of them 112 were identified to be associated with urosepsis. The mean age of the urosepsis patients was 46.26 years (SD 17.24) and 65.1% were females. The prevalence of Extended spectrum beta lactamase production (ESBL), as screened by disc diffusion testing using ceftazidime was almost similar in the two groups, 76% in the isolates from urosepsis, and 72% in the other group (p value>0.05). Carbapenem resistance was found in 3.1% of urosepsis isolates. On the other hand, about 13% of the non urosepsis E. coli isolates carbapenem resistance (p value<0.05). We here with report high prevalence of ESBL production in blood stream E. coli isolates. In E. coli isolates associated with urosepsis, higher susceptibility towards aminoglycosides and carbapenems was seen. Thus these two groups can serve as empiric antibiotics of choice in a female patient with known predisposing factors for developing a UTI, and presenting with signs and symptoms of urosepsis.
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