National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The incidence of extended spectrum beta lactamase producing strains among clinical isolates has been steadily increasing over the past few years resulting in limitation of therapeutic options available.8,16Therefore we conducted this study to determine the prevalence and antibiotic susceptibility pattern of ESBL producers among Escherichia coli and Klebsiella pneumoniae isolates in the north west region of the state, as the prevalence and antimicrobial susceptibility of ESBL-producing pathogens varies from one region to another. This study was carried out in the Department of Microbiology, Sardar Patel Medical college, Bikaner from April 2009 to May 2010 on a total of 700 clinical isolates including 520 Escherichia coli and 180 Klebsiella pneumoniae. In the present study ESBL production was noticed in 65.57% isolates with maximal incidence in Escherichia coli (66.92%) followed by Klebsiella pneumoniae (61.67%) isolates. The antimicrobial resistance was significantely higher in ESBL producer than non-ESBL producer. Among ESBL producer high rate of resistance to various antibiotics was seen (cefotaxime, ceftazidime, ceftriaxone, norfloxacin, cotrimoxazole). These high rates of resistance to various antibiotics may be due to various factors like-plasmid mediated transmission of ESBLs, poorly directed therapy and over-the-counter sales of antibiotics.
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