The study was aimed at evaluating the prevalence and multidrug resistance of bacteria isolates recovered from patients with clinically diagnosed postoperative surgical wound infections. Bacteria isolates were recovered from 362 swabs specimens of patients from University of Benin Teaching Hospital(UBTH) and Nnamdi Azikiwe University Teaching Hospital (NAUTH). A cross sectional study was adopted for this research and the specimens were obtained using the randomized sampling method and samples were cultured on Blood and MacConkey agar media and incubated aerobically and anaerobically for 48 hours. Phenotypic characterizations of bacteria isolates from both locations were confirmed molecularly to be (100%). These bacteria isolates were then subjected to Antibiotic susceptibility testing by Kirby-Bauer disk diffusion technique on Mueller-Hinton agar. The result shows that one hundred and twenty two (33.7%) surgical wound bacteria isolates which included four different genera (P. aeruginosa, E. coli, P. mirabilis and S. aureus) were recovered from postoperative surgical wound swab specimens. Prevalence of multidrug resistant isolates were found to be drastically high in both locations (UBTH= 78%, NAUTH= 85%; OR= 1.182; P value= 1.000). There were no significant differences (P>0.05) in the isolation of pathogens with respect to locations. Isolates exhibited highest resistance to Augmentin, Cefuroxime and cefixime from both locations and least resistance to Imipenem among the antibiotics tested against Gram negative isolates. The most predominant isolates from both locations were P. aeruginosa (UBTH=60%; NAUTH= 36%) and E. coli (UBTH=34%; NAUTH=52%). They exhibited high preponderance of multidrug resistance in both locations (P. aeruginosa, UBTH (90%), NAUTH (92%); E. coli, UBTH (70%), NAUTH (95%). Also UBTH registered 78% multidrug resistance while NAUTH had 85%. Surgical wound infections with resistant bacteria constitute a significance cause of morbidity in the study area. Findings in this study justify the need to strengthen infection control and treatment should be based on current laboratory susceptibility test results, and greater collaboration between microbiologists and clinicians to prevent the spread of multidrug resistant bacteria

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