National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Recent evidence from various lines of research suggested that low levels of vitamin D are associated with high levels of hepatitis B virus (HBV) replication in chronic hepatitis B (CHB) infection. However, the relationship between vitamin D and occult hepatitis B infection (OBI) remains unclear. To investigate the pattern of 25 hydroxy vitamin D levels in patients with OBI, we compared serum level of vitamin D among 52 patients with CHB infection, 16 patients with OBI and 34 age & sex matched healthy control. Hepatitis B envelope (HBe) antigen was assayed among CHB patients. Also, we quantified HBV DNA viral load among both CHB and OBI groups by using Real time PCR. We found that serum level of vitamin D was significantly higher in patients with OBI than those with CHB infection but it was insignificantly differ from healthy control. Patients with HBe Ag negative had a significantly higher serum level of vitamin D than those with HBe Ag positive. Serum level of vitamin D was inversely correlated with HBV DNA viral load. It could be concluded that adequate levels of vitamin D may be one of the factors limiting the replication of HBV and decreasing viral load in patients with OBI.
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