National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Development of biomarkers for psychiatric disease still remains challenging. Recently, numerous alterations in the expression of microRNAs (miRNAs) in peripheral blood, serum and post-mortem brain tissue have been linked to schizophrenia. Additionally, it is known that miRNAs can inactivate a target mRNA sequence through binding to its 3’UTR region. Thus, miRNAs might not only serve as prognostic biomarkers for diagnosis or prognosis of pathological conditions like schizophrenia, but could also actively modulate gene function. Therefore, the aim of this study was to test whether specific miRNA display differential expression in patients with schizophrenia vs. healthy controls by using miRNA microarray assay. Venous blood samples of 33 affected patients and 25 healthy controls were collected and the quantification of microRNAs was established using miRNA microarray assay. Moreover, we searched for potential validated target genes for each of the differentially expressed miRNAs that might play a role in the regulation of schizophrenia susceptibility genes.
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