National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
P.aeruginosa biofilms can offer resistance to antibiotics, and have evolved mechanisms to evade innate and acquired immune systems. Biofilms infection causes stimulation of innate and acquired immune systems. However, their persistent activation may result in more immune-mediated tissue damage with limited success in the removal of the biofilm pathogen. In this study we evaluated the potential of the serum raised against P. aeruginosa biofilm antigen in reducing and removing P. aeruginosa biofilms. We raised polyclonal sera in a Rabbit against P. aeruginosa biofilm antigens. The efficacy of the antigen was tested using slide agglutination test. We finally tested the efficacy of polyclonal sera to reduce and remove biofilm formation. We found that the anti-sera from rabbit showed strong immune response and disinfection activity against P. aeruginosa biofilm antigens. Passive immunotherapies can be important in attenuating acute P. aeruginosa infection and interfering with chronic infection.
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