National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Tumor necrosis factor (TNFα) plays an important role in autoimmune pathogenesis and is the main therapeutic target of rheumatoid arthritis (RA). TNFα signals via 2 receptors, TNF type 1(TNFRI) and (TNFRII) signaling are mainly activated by membrane TNF (m TNFα). The present study was aimed to investigate the role of TNF – α RII gene polymorphisms in susceptibility and severity of rheumatoid arthritis. Fifty RA patients and 50 apparently healthy controls were enrolled in the study. Genotyping of 196M/R polymorphism of TNFRII gene was determined by PCR-RFLP. Results were suggested that TNFRII196M/R polymorphism were associated with RA susceptibility. There was a significant difference in the genotype frequencies polymorphism of the TNFRII 196M/R between control and RA patients (p<0.05) (p<0.01).
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